表現型平均値（mg/日）§mm Mm MM6.055 4.014 3.688 ANGPT16.055 3.989 3.693 ANGPT13.157 3.821 3.9065.542 3.749 3.7564.829 3.648 3.776 PCDH97.046.073 3.603 3.7924.362 3.687 3.71 APOBEC14.342 3.756 3.6365.129 3.755 3.7455.479 3.742 3.758 TNR5.479 3.742 3.761 TNR4.353 3.683.7255.004 3.648 3.7864.345.766 3.932 3.7234.622 3.805 3.6734.316 3.654 3.7594.316 3.654 3.7594.602 3.723 3.732 MYRFL4.523 3.647 3.781 SCN5A4.783 3.872 3.664.387 3.711 3.716.835 3.909 3.7553.406 3.977 3.802 DGKB4.294 3.656 3.7496.822 3.689 3.7764.422 3.657 3.767 UBASH3B遺伝子型分布§mm/Mm/MM5/88/3325/90/33051/162/2127/106/31219/131/2752/53/3704/67/35455/197/17359/192/17011/104/3107/82/3367/82/33554/201/17013/123/28956/185/1845/75/34526/169/23059/213/15359/213/15327/166/23232/170/22318/152/25546/193/1862/39/38499/185/14060/212/1522/38/38441/180/204112/189/124 3.435 3.998 3.772 DGKB60/212/15360/212/15360/212/1532/66/35777/222/12631/155/23931/152/24256/183/1863/89/33111/95/3198/100/3178/100/3175/81/3398/95/32022/162/24122/162/24110/103/31287/204/13436/163/22340/168/21769/219/1373.826 3.763.728 3.674.294 3.656 3.7594.294 3.656 3.7594.294 3.656 3.7593.942 3.737 MCHR26.794.222 3.742 3.589 PTPRA3.859 3.83 COL6A63.053.053.849 3.836 COL6A64.312 3.674 3.732 HHIPL16.218 3.841 3.746 GABBR25.035 3.462 3.8365.256 3.715.256 3.715.653 3.823 3.747 RBFOX15.256 3.688 3.7783.751 GRIP12.915 3.952.915 3.953.751 GRIP15.091 3.757 3.75 NALCN4.182 3.628 3.7624.445 3.759 3.69 C2orf913.158 3.853 3.8454.241 3.672 3.732 STOX2表3 オピオイド投与量の表現型に対するRecessive model（Rec）によるゲノムワイド関連解析結果の上位候補遺伝子多型ランクdbSNP rs#染色体番号8831013rs1283671rs1283720rs10937129rs10749151rs9529111Rec1Rec1Rec3Rec4Rec5Rec6Rec7Rec8Rec9Rec10Rec11Rec12Rec13Rec14Rec15Rec16Rec17Rec18Rec18Rec20Rec21Rec22Rec23Rec24Rec25Rec26Rec27Rec28Rec29Rec30Rec30Rec30Rec33Rec34Rec35Rec35Rec37Rec38Rec39Rec40Rec40Rec42Rec43Rec44Rec44Rec46Rec47Rec48Rec49Rec50全解析結果中上位候補50遺伝子多型についての結果のみ提示。§: mm、マイナーアレルホモ接合; Mm、ヘテロ接合; MM、メジャーアレルホモ接合。rs117964643kgp2401165kgp12247990rs11692586rs12119177rs859468rs2131287rs4734909rs10758669rs4620259rs763434rs9896204rs9896751rs789559kgp8286424rs8019184kgp63935551:118813000rs12538534rs12453607kgp3351958rs7117189kgp11942343rs7221455rs4594287rs4271635rs17059990kgp10722247rs1022033rs7636656rs128900209 GSA-rs73488500rs7232372rs11747478rs4869419rs74007038rs12657207rs10878494rs7310442rs7982539rs47038422:42166453rs41396146rs230994218551651212135234遺伝子名RYR23.773.77がん患者における疼痛治療の効果に関わる遺伝子要因の探索p値（症例全体）染色体上Position107421459 0.000001584107460100 0.000001584183433872 0.000007607114017465 0.0000110266652839 0.000012549 GSA-rs72752701 125992274 0.000015269075197 0.0000162917656831 0.0000164712239430820 0.000017582134159434 0.000022782175409558 0.000022841175412790 0.000023511188022736 0.00002708491861390 0.0000285384981602 0.000028899108979439 0.000029958124504945 0.00003626753812816 0.000037521753813154 0.000037521769938313 0.000038761238615989 0.00004654382861117 0.000050414237610127 0.000050531118270377 0.00005196114159018 0.00005469753806149 0.0000556917122754906 0.000056226122678506 0.000058011114167835 0.00005852753801533 0.000064821753802812 0.000064821753807433 0.000064821799980179 0.0000671862924122 0.0000701320130645679 0.000072393130649457 0.00007239399648101 0.000072531498542975 0.0000765727922827 0.0000836993205828 0.00008493231833 0.0000846785856 0.0000842493235957 0.0000875866673327 0.0000911566675223 0.00009115101249487 0.0000913481760818 0.000098641939313 0.0000995324951006 0.0001025183918676 0.0001026137
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