臨床薬理の進歩　No.43

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表現型平均値（mg/日）§mm Mm MMNA 4.836 3.7214.088 4.484 3.694 DLGAP1,DLGAP1-AS46.196 4.942.691 4.743 3.718 DLGAP1,DLGAP1-AS4遺伝子型分布§mm/Mm/MM0/24/4012/47/3761/14/4091/27/3960/2/42310/95/3201/67/3560/3/4224/74/3467/116/3020/4/4212/49/3741/12/4032/44/3765/113/2984/80/3410/3/4220/2/4215/110/3100/7/4181/52/3684/79/3410/4/4201/7/4167/81/3371/9/4140/5/42014/115/2960/4/4210/4/4210/4/4210/4/4211/30/39333/151/2362/45/37812/112/2990/6/4197/87/3314/69/3520/13/4120/13/4120/21/3910/39/3860/27/3970/12/4136/66/3535/76/3440/4/4212/63/3602/18/405NA 7.188 3.7674.887 4.114 3.651 ACMSD1.558 4.351 3.688NA 6.435 3.765 TNR3.442 4.302 3.6823.877 4.148 3.641 LINC00982NA 6.068 3.7624.088 4.399 3.701 DLGAP1,DLGAP1-AS46.196 4.888 3.724.653 4.413.634.168 3.6543.388 4.268 3.675 BFSP2NA 6.381 3.765 SEC23IPNA 6.972 3.773 TGIF13.521 3.422 3.916NA 5.466 3.7554.263 4.364 3.7043.388 4.267 3.681 BFSP2NA 5.976.399 5.178 3.752 WDR493.928 4.227 3.674 BFSP25.969 5.07NA 5.738 3.763.956 4.125 3.643 FHITNA 5.548 3.758 LOC1001336693.535 4.233.908 4.264 3.688NA 4.956 3.747NA 4.948 3.747 GABRB2NA 4.697 3.746NA 4.427 3.719NA 4.569 3.731 DARS-AS1NA 4.983.7494.528 4.208 3.692 RXRA4.613 4.176 3.685NA 5.868 3.764 DSCAM4.223 4.263 3.6974.738 4.692 3.738dbSNP rs#染色体番号101811892411216181673101886938331963888346618853115127219321142rs77717582kgp81134331:213021921rs46322269:133013640rs12622574kgp12124975rs755431252rs110466863066299 0.00001668kgp1514239079747227 0.000016976:804569443967852 0.00001703rs79747906212812250 0.000018911:212985592-GA155423485 0.00002099JHU_6.15574461881203825 0.00002252JHU_7.80833140133444070 0.00002261JHU_3.133162913119912126 0.00002351rs7633152923452225 0.0000240518:3452222121157925 0.00002637kgp839824544515301 0.000026496:444830384985085 0.000029479:4985085133444647 0.00003135rs7546911240463470 0.000032578:40320989167633572 0.000035193:167351360133462226 0.00003531rs987349212200646 0.0000385819:123114617204430 0.000038926:720466360604330 0.00003931rs72402540458420 0.000039328:4031593940469848 0.000039328:4032736740470473 0.000039328:4032799239630484 0.00004118rs117341459113850347 0.00004148kgp21107480167391158 0.00004173JHU_6.167804645155424053 0.00004255kgp253917675163372 0.00004381rs744142142986125 0.00004619rs7371791511378194 0.00005007rs11948339JHU_3.1916856819127077 0.00005109JHU_11.134578732 134708839 0.00005908161311253 0.00006684rs14577827756195879 0.0000766612:5658966325926270 0.00008051rs7805035136003505 0.000082842:13676107518045740 0.00008413kgp15630468134429410 0.00008589rs6413517125409833 0.00008854rs1093471340088382 0.00008997rs18859631485343567 0.00009021rs17796783233859961 0.00009207kgp14155532表2　オピオイド投与量の表現型に対するDominant model（Dom）によるゲノムワイド関連解析結果の上位候補遺伝子多型ランクDom1Dom1Dom3Dom4Dom5Dom6Dom7Dom8Dom9Dom10Dom11Dom12Dom13Dom14Dom15Dom16Dom17Dom18Dom18Dom20Dom21Dom22Dom23Dom24Dom25Dom26Dom27Dom28Dom29Dom30Dom30Dom30Dom33Dom34Dom35Dom35Dom37Dom38Dom39Dom40Dom40Dom42Dom43Dom44Dom44Dom46Dom47Dom48Dom49Dom50全解析結果中上位候補50遺伝子多型についての結果のみ提示。§: mm、マイナーアレルホモ接合; Mm、ヘテロ接合; MM、メジャーアレルホモ接合。 NA、Not Availabe。p値（症例全体）染色体上Position126393947 0.0000006073970901 0.000001732212848579 0.0000046653989188 0.000005012130251361 0.000005987134846922 0.00000752285423392 0.00001002175365091 0.0000157722904370 0.0000159遺伝子名3.741TATDN33.71 NOX33.7563.753 LOC100289333RREB13.763NA 5.973.763NA 5.97NA 5.973.763NA 5.964 3.7634.111 4.556 3.7244.315 3.974 3.6044.653 4.373 3.709 NOX33.507 3.443 3.9153.672 CTNND2136