p値遺伝子名RYR2表1 オピオイド投与量の表現型に対するAdditive model（Add）によるゲノムワイド関連解析結果の上位候補遺伝子多型ランク染色体染色体上番号（症例全体）Position8Add11074214590.00000069068Add11074601000.00000075263Add31834338720.0000067652Add42394308200.00001174Add5101140174650.000012179GSA-rs727527011259922740.00001491Add6828611170.0000159614Add71245049450.000017577Add81908802690.000019911Add9Add10190751970.000020831794391350.000020932Add111089794390.000021228Add121341594340.000024412Add13Add1411754095580.000025091754127900.000025991Add15666528390.0000311813Add161717864830.000033433Add171718031990.000034033Add18Add1881006081460.0000396349816020.000040529Add2029241220.0000430520Add21820352920.0000438616Add221182703770.000048491Add23Add246999801790.0000556918613900.000056458Add251227549060.000059856Add26699383130.0000621212Add27202603740.0000652721Add28Add299GSA-rs73488500985429750.000068752449702480.000071411Add301:24513354967858560.0000770316Add30rs7400703876568310.0000776612Add30kgp2401165Add3321202668100.0000813221:21639123247317920.00008523Add34kgp8402535419393130.000087712Add352:42166453imm_22_2893656422Add35302105750.0000879JHU_2.2284675632276028480.000088352Add37Add3816kgp3873565896188260.000096251012494870.00009693rs798253913Add39932058280.0001041rs117474785Add405Add40932318330.0001041rs4869419116264390.0001102kgp24649520Add42Add4323rs376159981729760.0001107932359570.0001146rs126572075Add441306494570.0001166rs76366563Add442449621970.00011711:2451254991Add462376101270.0001208kgp63935551Add47Add486rs77892998774446370.0001228120991180.0001249GSA-rs10960477Add49Add5016553088680.0001245全解析結果中上位候補50遺伝子多型についての結果のみ提示。§: mm、マイナーアレルホモ接合; Mm、ヘテロ接合; MM、メジャーアレルホモ接合。dbSNP rs#rs1283671rs1283720rs10937129kgp12247990rs10749151rs8019184rs763434rs10800988rs117964643exm2265241rs4620259rs11692586rs12119177rs859468rs9529111rs4894509rs67878218:101620374rs10758669kgp10722247kgp19589261:118813000rs17059990rs4734909kgp3351958rs789559rs2826111rs75384045表現型平均値（mg/日）§mmMmMM6.0554.0143.688ANGPT16.0553.9893.693ANGPT13.1573.8213.9064.3423.7563.6365.5423.7493.7567.043.8263.764.7833.8723.664.6223.8053.6734.1723.8043.5456.0733.6033.7923.3883.8054.0255.7663.9323.7235.1293.7553.7455.4793.7423.758TNR5.4793.7423.761TNR4.8293.6483.776PCDH94.1643.8093.547PLD14.1533.8213.541PLD14.1973.7563.581SNX314.344.2223.7423.589PTPRA4.2313.8873.56HSD17B26.8353.9093.7556.795.0043.6483.7866.8223.6893.7764.6023.7233.732MYRFL4.3563.8153.6416.2183.8413.746GABBR24.2633.8453.598LOC101928068,EFCAB25.6533.8233.747RBFOX14.3623.6873.71APOBEC14.3563.8033.654.4783.813.6744.4453.7593.69C2orf915.834.584.7713.7773.729DPEP15.0913.7573.75NALCN3.775.2563.715.2563.713.775.3213.8283.7392.2753.5223.8165.2563.6883.7783.054.2953.7853.6444.3873.7113.714.8763.8563.715.5963.8643.7466.1263.9163.746遺伝子型分布§mm/Mm/MM5/88/3325/90/33051/162/21259/192/1707/106/3122/53/37018/152/25526/169/23082/193/1504/67/35487/215/1235/75/34511/104/3107/82/3367/82/33519/131/27580/198/14680/193/15281/206/13856/185/18477/222/12654/180/1912/39/3842/66/35713/123/2892/38/38427/166/23243/171/2113/89/33151/174/1955/81/33955/197/17343/172/21031/159/23536/163/2234/54/36723/151/25117/113/29510/103/3128/100/3178/100/3177/87/3317/12/4058/95/32031/152/24251/185/18946/193/18613/123/2875/57/3633/52/3703.7283.673.9423.737MCHR24.023.7273.8573.6663.8493.836COL6A6135
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