p-trend = 3.6 × 10-4p-trend = 0.54p-trend = 0.57p-trend = 0.23p-trendC-LDLdetsujdA)Ld/gmstnapcitrapforebmuN05100105i00( LDL-C600400200MedianPRS LDL-C =0.065＊-0.50.00.5MedianPRS LDL-C =0.032＊-0.50.00.5230［207-266］232［212-273］221［197-250］122［102-144］MedianPRS LDL-C =0.101＊†-0.50.00.5217［191-255］218［190-251］242［205-294］234［206-273］197［183-225］210［190-241］128［106-149］132［113-157］MedianPRS LDL-C =0.007-0.50.00.230.570.543.6×10-40.5ControlsT1T2T3PRSLDL-Cmutation-negative FHmonogenic FH0.120[0.011-0.270]0.011*–ControlsAll FHT1T2T3All FHmonogenic FHLDL-Cmutation-negative CDFHControlsmonogenic FHT1T2T3T1mutation-negative CDFHT1T2T3TERTILEPRStertileT2T3All FHmonogenic FHmutation-negative CDFHAll FH0.156[0.042-0.294]5.4 × 10-9 ＊–図2 PRSLDL-Cヒストグラム表3 PRSLDL-Cの群間比較（LDLコレステロール）PRSLDL-Cp value compared to Controlsp value compared to monogenic FH各群間比較はt検定を用いた。median［95％CI］ ＊：p＜0.05 †：vs monogenic FH図 3 PRSLDL-C 3分位別 LDL コレステロール値トレンド検定PRSLDL-Cの3分位に分割し、LDLコレステロール値のトレンド検定を行った。志賀町コホート（Controls）0.0723[-0.051-0.180]––0.199[0.076-0.307]5.1 × 10-9 ＊0.024 †120
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